Differin contains the only full prescription fighting retinoid available over the counter: adapalene. It’s the first new OTC active ingredient to treat acne approved by the FDA in more than 30 years. Prevents breakouts, blackheads, white heads, blemishes and clogged pores. Restores skin tone and texture by clearing acne. Prescription no longer required. Limit sun exposure, including light from tanning beds, and use sunscreen when going out. Use once daily, even if you don't see breakout. Consistent use is the key.